![]() Tight binding inhibits enzyme activity, and consequent cell wall formation. The 4 ring structure and associated side groups result in tight binding to the active site of transpeptidases (also known as Penicillin Binding Proteins). This ring mimics the shape of the terminal D-Ala-D-Ala peptide sequence that serves as the substrate for cell wall transpeptidases that form covalent bonds between different peptidoglycan chains during periods of cell growth. All beta-lactam antibiotics contain the same core 4-member “beta-lactam” ring (highlighted in red). Core structure of beta-lactam antibiotics. All members of the superfamily of antibiotics known as “beta-lactams” have a core structure consisting of a 4-member “beta-lactam” ring (Figure 1).įigure 1. ![]()
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